What is a true statement regarding SUMOylation?

SUMOylation is a post-translational modification where a small ubiquitin-like modifier (SUMO) protein is attached to a target protein. This modification is particularly significant in the context of regulating various nuclear processes, including transcription and nuclear transport. When SUMO is conjugated to transcription factors or other nuclear proteins, it can influence their activity, stability, localization, and interaction with other proteins, making it crucial for the regulation of gene expression and the transportation of proteins into and out of the nucleus.

In the context of transcription, SUMOylation can affect how transcription factors bind to DNA or interact with coactivators and corepressors, thus altering the overall transcriptional output. Additionally, SUMOylation can play a role in the nuclear transport of proteins by facilitating their passage through the nuclear pore complex and influencing their localization within the nucleus.

Overall, the connection of SUMOylation to transcription and nuclear transport highlights its essential role in cellular signaling and the orchestration of gene expression, making this statement a true reflection of its function.