What is the ΔG change when ATP is hydrolyzed to ADP and inorganic phosphate?

The change in free energy (ΔG) when ATP is hydrolyzed to ADP and inorganic phosphate is indeed negative. This negative ΔG indicates that the reaction is exergonic, meaning it releases energy. Hydrolysis of ATP is a key biochemical reaction utilized by cells to perform work.

When ATP is hydrolyzed, the high-energy phosphate bonds are broken, resulting in the formation of ADP and inorganic phosphate. This process releases energy that can be harnessed for various cellular functions, such as muscle contraction, active transport across membranes, and biosynthesis of macromolecules. The spontaneity and energy release of this reaction make it a crucial driver of many biological processes.

Consequently, the negative ΔG reflects the reaction's favorability under standard conditions, confirming that ATP hydrolysis is a primary source of energy for cellular activities. This is why the provided answer correctly identifies the ΔG change as negative.