Which statement about enzymes is true?

Enzymes are biological catalysts that significantly increase the rate of chemical reactions without undergoing any permanent changes themselves. They achieve this by lowering the activation energy required for a reaction to proceed, which allows reactants to convert to products more quickly. The presence of an enzyme facilitates a more efficient transition state, enabling the reaction to occur faster than it would in the absence of the enzyme.

While it's true that enzymes do not alter the change in free energy (ΔG) of a reaction, they make it possible for reactions to reach that state more rapidly. Therefore, the statement regarding enzymes increasing the rate of a chemical reaction is accurate, as this is a fundamental characteristic of how enzymes function in biochemical processes.

The other statements discuss aspects that are not true about enzymes: they do not change the ΔG of reactions nor do they directly couple reactions to ATP condensation as part of their primary function; rather, some enzymes are involved in metabolism where ATP is utilized or generated, but this is not a universal property of all enzymes.